Business homework help. Significance of the Differences Between Mitosis and MeiosisMendel used mathematics and experimentation to derive major principles that have helped us understand inheritance. His ideas were totally different than the explanation for passage of characteristics from parents to offspring that was common to his time. Discuss at least two of his principles in detail, providing examples. Describe how each principle contributes to genetic variability. Discuss the significance of Mendel’s discoveries to modern biology.